Thank you.

Just look at the difference just 20-30 rock solid Tea Party conservatives have made in the House already. They’ve turned “1/3 of the government” on its head and started a war between the establishment party and the Tea Party.

Hello,

I like to be a part of this good forum.

Kathy, the content you have graciously shared with us every once in a while is both inspiring and entertaining. And a blog is the perfect medium for this. A lot of the content is about your style and creative personality. Thus, I would rule out the community-based ideas. I would probably only read your stuff anyway.

Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs) are involved in relaying extracellular stimulations to intracellular responses. The MAPKs coordinately regulate cell proliferation, differentiation, motility, and survival, which are functions also known to be mediated by members of a growing family of MAPK-activated protein kinases (MKs; formerly known as MAPKAP kinases). The MKs are related serine/threonine kinases that respond to mitogenic and stress stimuli through proline-directed phosphorylation and activation of the kinase domain by extracellular signal-regulated kinases 1 and 2 and p38 MAPKs. There are currently 11 vertebrate MKs in five subfamilies based on primary sequence homology: the ribosomal S6 kinases, the mitogen- and stress-activated kinases, the MAPK-interacting kinases, MAPK-activated protein kinases 2 and 3, and MK5. In the last 5 years, several MK substrates have been identified, which has helped tremendously to identify the biological role of the members of this family. Together with data from the study of MK-knockout mice, the identities of the MK substrates indicate that they play important roles in diverse biological processes, including mRNA translation, cell proliferation and survival, and the nuclear genomic response to mitogens and cellular stresses. In this article, we review the existing data on the MKs and

I hate to see us lose your input but I wonder if simply publishing articles with no comments enabled and having a members-only forum wouldn't be a good compromise. There's something about the immediacy of the response form and the lack of accountability available from anonymity (oh, hypocritical me) that seems to encourage people's awfulness.

Good for Hannity, hammering Mc Cain. Mc Cain off as so slimey. He completely bought into the Obama narrative and talks about the great calamity to come if there is no agreement, and continues to blast the Tea Party.

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I always wondered if the Manchurian Candidate – McLame – would make an appearance. I think he is a victim of Stockholm Syndrome, too.

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